Multilocus Sequence Typing (MLST)

Multilocus sequence typing (MLST) is an unambiguous procedure for characterising isolates of bacterial species using the sequences of internal fragments of (usually) seven house-keeping genes.

General

• Neisseria MLST website (pubmlst.org)

Project databases

These databases are for specific projects or publications.

• Czech Neisseria meningitidis carriage population database
  • This database contains full details of isolates described in Jolley et al. (2000) Carried meningococci in the Czech Republic: a diverse recombining population, J Clin Microbiol, 38:4492-98 and Jolley et al. (2004) 'The influence of mutation, recombination, population history, and selection on patterns of genetic diversity in Neisseria meningitidis.' Mol Biol Evol 2005, 22:562-9. The full study is published in Buckee et al. (2008). 'Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis.' Proc Natl Acad Sci USA, [Epub ahead of print].
• Czech, Greek and Norwegian EU-MenNet Study isolate database
  • This database contains information for 667 isolates of Neisseria meningitidis recovered from healthy carriers and patients with meningococcal disease from three European countries between 1991 and 2000. See Yazdankhah et al. (2004) Distribution of serogroups and genotypes among disease-associated and carried isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway, J Clin Microbiol, 42:5146-53.
  • These data have also been submitted to the PubMLST.org database.
• ST-23 serogroup Y database
  • Password protected